Canagliflozin extends life span in genetically heterogeneous male but not female mice
نویسندگان
چکیده
منابع مشابه
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were...
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BACKGROUND Little is known about the number or chromosomal location of genetic loci that might identify individuals destined to have a long life span. Analysis of gene/life span associations in mice, which are short-lived compared to humans, might provide guidance for an analysis of the genetic basis of life span in humans. METHODS A group of 144 genetically heterogeneous mice, produced by a ...
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E vidence that calorie restriction (CR) retards aging and extends median and maximal life span was fi rst described in the 1930s by McCay et al. [1]. Since then, similar observations have been made in a variety of species including rodents, fi sh, fruit fl ies, worms, and yeast [2]—and although they are not yet defi nitive, results from ongoing longevity studies in monkeys suggest that CR will ...
متن کاملPain reduces sexual motivation in female but not male mice.
Chronic pain is often associated with sexual dysfunction, suggesting that pain can reduce libido. We find that inflammatory pain reduces sexual motivation, measured via mounting behavior and/or proximity in a paced mating paradigm, in female but not male laboratory mice. Pain was produced by injection of inflammogens zymosan A (0.5 mg/ml) or λ-carrageenan (2%) into genital or nongenital (hind p...
متن کاملPappa2 deletion in mice affects male but not female fertility
BACKGROUND Recent studies have found associations between the gene encoding pregnancy associated plasma protein-A2 (PAPP-A2), a protease of insulin-like growth factor binding protein -5 (IGFBP-5), and measures of female reproductive performance in cattle. The purpose of the present study was to test the effects of Pappa2 deletion on reproduction in mice. FINDINGS We measured the fertility and...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2020
ISSN: 2379-3708
DOI: 10.1172/jci.insight.140019